Bacterial Endotoxin Testing

Endotoxin exposure will cause severe inflammation, a drop in blood pressure, organ failure and possible death — and it’s a serious problem in the injectable pharmaceuticals industry, where the presence of endotoxin is regulated. All sterile, injectable drugs, the devices used for injection and the water used to produce them are required to meet acceptable levels of endotoxins before the material can be sold.

Call EMSL to keep your products and facilities safe, compliant and endotoxin-free. Our analytical testing labs provide endotoxin detection services with accurate results and quick turnaround. Let EMSL be your partner in limiting endotoxin exposure — contact us today to learn more about our endotoxin testing services!

What is Endotoxin?

Endotoxin is a lipopolysaccharide component of the cell wall of gram negative bacteria. The wide-spread presence of these bacterial organisms makes endotoxin ubiquitous in the environment — it’s often found in conjunction with flooding and water damaged buildings, wastewater treatment plants, agricultural facilities and some textile operations.

The Importance of Endotoxin Testing

In indoor environments and certain industries, endotoxin exposure may be airborne. Contaminated dust and water must be aerosolized in order for endotoxin to be transmitted. In these settings, endotoxin exposure is associated with fever and flu-like symptoms, can exacerbate asthma symptoms, or cause pneumonitis. After a flood, gram negative bacteria are the first organisms to multiply (even before fungi) — therefore, if a flood has occurred on your property, it’s important to test for endotoxin in addition to mold and other organisms.

Endotoxin is very persistent and may even be present in sterile material. Heat treatment is the only way to inactivate endotoxin. Endotoxin’s characteristics have important implications for product sampling — all vials for liquid/bulk samples and cassettes used for air or dust sampling must be certified as endotoxin free.  Details for endotoxin sampling can be found in EMSL’s Microbiology Sampling Guide.

Need endotoxin testing services for your facility? EMSL’s microbiology labs will partner with you, delivering accurate results, quick turnaround and a custom analysis to suit your specific testing needs. Contact EMSL today to learn more about our bacterial endotoxin testing services.

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